Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.100 Biomarker BEFREE Mutational status of PIK3ca oncogene in oral cancer-In the new age of PI3K inhibitors. 31831300

2020

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.100 Biomarker BEFREE Mutational status of PIK3ca oncogene in oral cancer-In the new age of PI3K inhibitors. 31831300

2020

Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.100 Biomarker BEFREE Mutational status of PIK3ca oncogene in oral cancer-In the new age of PI3K inhibitors. 31831300

2020

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.100 Biomarker BEFREE Mutational status of PIK3ca oncogene in oral cancer-In the new age of PI3K inhibitors. 31831300

2020

Entrez Id: 2072
Gene Symbol: ERCC4
ERCC4
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.010 Biomarker BEFREE To investigate a possible role for DNA nucleotide repair proteins in oral cancer behavior, this study evaluated the immunoexpression of the proteins TFIIH and XPF and its association with clinical, histological, and survival parameters in oral tongue squamous-cell carcinoma (OTSCC). 31828418

2020

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.100 Biomarker BEFREE EGFR enhances the stemness and progression of oral cancer through inhibiting autophagic degradation of SOX2. 31823521

2020

Entrez Id: 6657
Gene Symbol: SOX2
SOX2
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.040 Biomarker BEFREE EGFR enhances the stemness and progression of oral cancer through inhibiting autophagic degradation of SOX2. 31823521

2020

Entrez Id: 3593
Gene Symbol: IL12B
IL12B
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.010 GeneticVariation BEFREE IL12B rs3212227 genotype was associated with oral cancer risk only in betel quid chewers. 31810916

2019

Entrez Id: 1493
Gene Symbol: CTLA4
CTLA4
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.030 AlteredExpression BEFREE Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4. 31804466

2019

Entrez Id: 406947
Gene Symbol: MIR155
MIR155
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.010 Biomarker BEFREE It was found that the expression of miR-155 is abnormally elevated in oral cancer tissues, suggesting that miR-155 may be a tumor-promoting gene for oral cancer. 31771044

2020

Entrez Id: 2309
Gene Symbol: FOXO3
FOXO3
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.010 Biomarker BEFREE MiR-155 targeting FoxO3a regulates oral cancer cell proliferation, apoptosis, and DDP resistance through targeting FoxO3a. 31771044

2020

Entrez Id: 142
Gene Symbol: PARP1
PARP1
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.030 Biomarker BEFREE PARP inhibitor Olaparib Enhances the Apoptotic Potentiality of Curcumin by Increasing the DNA Damage in Oral Cancer Cells through Inhibition of BER Cascade. 31768967

2019

Entrez Id: 1302
Gene Symbol: COL11A2
COL11A2
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.010 Biomarker BEFREE PARP inhibitor Olaparib Enhances the Apoptotic Potentiality of Curcumin by Increasing the DNA Damage in Oral Cancer Cells through Inhibition of BER Cascade. 31768967

2019

Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.100 Biomarker BEFREE Migration is regulated by EP4/PI3K/Orai1 signaling in oral cancer. 31755615

2020

Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.100 Biomarker BEFREE Migration is regulated by EP4/PI3K/Orai1 signaling in oral cancer. 31755615

2020

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.100 Biomarker BEFREE Migration is regulated by EP4/PI3K/Orai1 signaling in oral cancer. 31755615

2020

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.100 Biomarker BEFREE Migration is regulated by EP4/PI3K/Orai1 signaling in oral cancer. 31755615

2020

Entrez Id: 285282
Gene Symbol: RABL3
RABL3
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.010 AlteredExpression BEFREE The expression of GIMAP7 was found to be down regulated in serum of patients suffering from oral cancer while the expression of Rabl3 was found to be up-regulated. 31748878

2019

Entrez Id: 168537
Gene Symbol: GIMAP7
GIMAP7
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.010 AlteredExpression BEFREE The expression of GIMAP7 was found to be down regulated in serum of patients suffering from oral cancer while the expression of Rabl3 was found to be up-regulated. 31748878

2019

Entrez Id: 6487
Gene Symbol: ST3GAL3
ST3GAL3
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.010 AlteredExpression BEFREE The study demonstrated significant role of elevated mRNA levels of ST3GAL2 and ST3GAL3 in disease progression and metastasis of oral carcinoma. 31747460

2020

Entrez Id: 6483
Gene Symbol: ST3GAL2
ST3GAL2
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.010 AlteredExpression BEFREE The study demonstrated significant role of elevated mRNA levels of ST3GAL2 and ST3GAL3 in disease progression and metastasis of oral carcinoma. 31747460

2020

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.070 Biomarker BEFREE In this study, we have developed a novel siRNA-based therapeutic strategy targeting BCL2 and BIRC5 for oral cancer. 31744202

2019

Entrez Id: 332
Gene Symbol: BIRC5
BIRC5
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.010 Biomarker BEFREE In this study, we have developed a novel siRNA-based therapeutic strategy targeting BCL2 and BIRC5 for oral cancer. 31744202

2019

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.030 Biomarker BEFREE In conclusion, AGG-induced degradation of NRF2 through autophagy leads to ROS accumulation dependent apoptosis which might be used for treatment of oral cancer. 31715238

2019

Entrez Id: 2551
Gene Symbol: GABPA
GABPA
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.030 Biomarker BEFREE In conclusion, AGG-induced degradation of NRF2 through autophagy leads to ROS accumulation dependent apoptosis which might be used for treatment of oral cancer. 31715238

2019